Tumors were histologically classified by certified pathologist as Dukes A (n=5), Dukes B (n=12), Dukes C (n=10) and Dukes D (n=2) corresponding to stage I–IV.
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Preclinical data, and an increasing list of clinical investigations, show anti‑inflammatory agents to favourably influence the biology of colorectal tumor.
Patients with tumors overexpressing COX-2, were reported to have the greatest improvement of survival in one study, while the beneficial effects of aspirin could not be attributed to high expression of COX-2 in another study, where HLA class I antigen appeared a covariate (4,6).
We have also reported that standard oral administration of NSAIDs for three days preoperatively to CRC patients, changed tumor m RNA and protein expression in a biologically favourable direction, when analyzed on whole human oligo microarrays and confirmed by Q-PCR and immunohistochemistry (IHC).
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The nearest airport is Shanghai Pudong International Airport, 7 miles from the property.Tumor stages within groups were: in controls (n=15), Dukes A (n=2), B (n=8), C (n=4), D (n=1) and in NSAID-treated patients (n=15), Dukes A (n=3), B (n=4), C (n=6), D (n=1), villous adenoma (n=1); NSAID treatment was indomethacin (Confortid, 50 mg × 2; Alpharma, n=11) or celebrex (100 mg × 2; Pfizer, n=4) during three preoperative days together with gastric prophylaxis (Nexium 40 mg × 1; Astra Zeneca, n=15), which was also provided as sham treatment to all control patients.None of the patients received radiochemotherapy pre- or postoperatively according to our local guidelines or patient preferences (Table I)..In further studies based on the same CRC patients, we found m RNA and the AC133 protein epitope expression of Prominin-1/CD133, a marker associated with stemness and poor prognosis in several solid tumors, to be downregulated, including some additional stem cell-related genes, which belonged to the families of WNTs and bone morphogenetic proteins (BMPs) (8–10).In the present study we have continued analyses on the same patient groups as described earlier, on preoperative NSAID treatment (7,8).Total RNA was extracted with RNeasy Fibrous Tissue Midi kit (Qiagen), where DNase treatment was included according to kit protocol.